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Project Code [2007-PhD-ET-9]
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Project title
Exploitation of sugar kinases in green chemistry
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
Queen's University Belfast (QUB)
Lead Applicant
David J Timson
Project Abstract
It is proposed to assess the potential of two related recombinant human enzymes ? galactokinase and N-acetylgalactosamine kinase ? as catalysts for low environmental impact site- and stereospecific phosphorylation of sugars.This will be achieved by1. Rational, structure-based mutagenesis of both enzymes to alter the substrate specificity thus providing new synthetic routes to sugar and N-acetyl sugar phosphates.2. Determining the effects of temperature, organic solvents and covalent immobilisation to a solid substrate (such as agarose or sepharose) on the enzymes to assess their suitability for use in scaled-up industrial processes.
Grant Approved
�95,000.00
Research Hub
Green and Circular Economy
Research Theme
Waste and Resources Management
Initial Projected Completion Date
01/10/2010