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Project Code [2007-PhD-EH-1]
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Project title
Role of engineered nanoparticles in protein fibrillation diseases
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
University College Dublin (UCD)
Lead Applicant
Kenneth Dawson
Project Abstract
The health and safety aspects of nanoparticles released into the environment (either intentionally, such as in controlled release products for agriculture, or accidentally, as waste products, spillages, etc.) is at present entirely unknown. What is known, is that nanoparticles can reach all areas of the body, including the brain, and that their enormous surface area offers potential for considerable adsorption of proteins, with subsequent alterations in protein aggregation and function. Our preliminary results show that nanoparticles such as cerium oxide (used in fuels and released as emissions) can modulate the rate of protein fibrillation in vitro, highlighting a pressing need for further research.
Grant Approved
�95,000.00
Research Hub
Healthy Environment
Research Theme
Environment and Human Health
Initial Projected Completion Date
20/08/2010