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Project title

Isolation, characterization and biological impacts of recycling silica nanoparticles

Primary Funding Agency

Irish Research Council

Co-Funding Organisation(s)

n/a

Lead Organisation

University College Dublin (UCD)

Lead Applicant

n/a

Project Abstract

When it comes to the bio-nanoscale recognition, interaction and biological safety of silica, various studies have been carried out. This includes investigation of the in vitro molecular biology mechanism and in vivo accumulation long-term affects-related studies. In 2019, CBNI reported the development of a 3D cell-culture platform which could be used for long-term observations of the bio-nanoscale interaction. This showed for the first time, that the long-term degradation kinetics of amorphous silica nanoparticles is affected by the architecture of the silica particles [1]. Although immense efforts have been put into the biosafety of the nanoscale materials field, most of the studies thus far have focused on the �bare� particles. An untouched area in this field is a study of the systematic biological impacts of those particles internalized by cells and then secreted with a new bio-coating on the surface of the particles. Whether these NPs with new coatings will have a different intracellular fate and thus induce a secondary toxicity? Questions like this have not been answered but are of vital importance for human health and environmental risk assessment, especially for companies like Intel who are a leader in the wide application of silica materials and their biosafety. The proposed project aims to set up such a framework for the isolation, characterization and exploration of the cells secreted silica�s cellular effect including cellular uptake rate, secondary toxicity and intracellular fate.

Grant Approved

�99,513.00

Research Hub

n/a

Research Theme

Climate Solutions, Transition Management and Opportunities

Start Date

09/01/2022

Initial Projected Completion Date

31/08/2024